desvenlafaxine will raise the degree or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, four hundred mg) decrease the CYP2D6 substrate dose by as much as fifty%; no dosage adjustment necessary with desvenlafaxine doses seven consecutive days
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